hPTK7/MC-38
CBPG0121
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产品描述
产品数据库
| I. Background | |
| PTK7 是一种缺乏催化活性的受体蛋白酪氨酸激酶，隶属于蛋白激酶家族，因最早在 结肠癌中被发现，故又被称为 cck-4。作为 Wnt/β-catenin 和 Wnt/PCP 信号通路的常见参与 者，PTK7 对这两种信号通路均有促进或抑制作用。PTK7 能与相应配体结合（即二聚化）、 并自身磷酸化激活下游一系列级联传递并调控细胞增殖、分化及凋亡。 PTK7 基因存在组 织特异性，在多种肿瘤中表达水平升高，其高表达于胃癌、结直肠肿瘤、乳腺癌、卵巢癌 等。 而在子宫颈癌、脂肪肉瘤、血液肿瘤中 ，PTK7 呈现为低表达。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hPTK7 |
| Stability: | 32 passages |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 6weeks, female |
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Implanted Position |
Subcutaneous (right lower flank region ) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hPTK7/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3.hPTK7/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
