PIK3CA p.C420R Reference Standard
CBP10328
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| Introduction | |
| Format | Genomic DNA |
| Description | PIK3CA C420R lies within the C2 PI3K-type domain of the Pik3ca protein (PMID: 17376864). C420R confers a gain of function on Pik3ca, as indicated by constitutive phosphorylation of downstream targets Akt and S6, and is transforming in cell culture (PMID: 17376864, PMID: 29533785). |
| Technical Data | |
| DNA Change | c.1258T>C |
| AA Change | p.C420R |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 60.00% |
| Transcript | NM_006218.1 |
| Cosmic ID | COSM757 |
| Chr position(GRCh37) | chr3:178927980 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
